Opportunity Information: Apply for W81XWH 19 CPMRP IIRA

The DoD Chronic Pain Management Research Program (CPMRP) Investigator-Initiated Research Award (IIRA), funding opportunity number W81XWH 19 CPMRP IIRA, is a Department of Defense research grant/cooperative agreement designed to push forward meaningful progress in chronic pain science and care. For FY19, the program is centered on a single focus area: "Chronification of Pain," meaning the biological, psychological, and environmental processes that drive the transition from acute pain to persistent, chronic pain. The core idea behind the opportunity is prevention at the mechanism level: by identifying the determinants that cause acute pain to become chronic, and by developing or testing approaches that can interrupt that progression, the program aims to reduce the number of people who ultimately need long-term pain management interventions and to improve quality of life for individuals at risk.

The award supports investigator-initiated projects, which means applicants are expected to propose their own compelling scientific questions and study designs within the chronification theme, rather than responding to a narrow, prescriptive set of experiments. The opportunity is intentionally broad in terms of research stage and methods. Proposed work can span basic research (including mechanistic studies and discovery work), translational research (bridging laboratory findings toward practical interventions), and clinically oriented research. Acceptable study platforms include animal models, research involving human anatomical substances, and studies involving human subjects. The program also allows ancillary studies tied to an existing clinical trial, which can be a useful pathway for teams that can leverage ongoing trial infrastructure or biospecimens to answer chronification-related questions efficiently. At the same time, a key boundary is explicit: the IIRA funding cannot be used to conduct a clinical trial itself, so projects must be planned accordingly (for example, focusing on observational human studies, biomarker validation, mechanistic patient phenotyping, or secondary analyses and add-on studies that do not constitute a new interventional trial under typical definitions).

From a programmatic standpoint, CPMRP is looking for work with a strong chance of producing significant advances in research knowledge, patient care implications, and/or measurable improvements to quality of life. In practical terms, competitive proposals would be expected to clearly connect the science to the chronification problem: identifying modifiable risk factors, mapping causal pathways, discovering predictive markers of chronic pain development, or developing non-trial therapeutic concepts that could later be advanced toward testing. The solicitation also emphasizes the value of multidisciplinary collaborations and innovative approaches, signaling that teams combining expertise across domains (for example, neuroscience, immunology, rehabilitation, psychology, data science, bioengineering, or systems biology) are welcome and may be particularly well-suited to unravel the complex, multi-factor nature of chronic pain onset.

Administratively, this is a discretionary DoD opportunity administered through the Department of Defense, Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). The funding instrument type is listed as both cooperative agreement and grant, which generally indicates that awards could vary in the level of agency involvement during project execution depending on the specific mechanism used. The activity category is science and technology and other research and development, and the CFDA number is 12.420. Eligibility is described as unrestricted, meaning it is open to any type of entity unless further limited by additional eligibility language in the full announcement. The opportunity record indicates an expected three awards. The original posting date was July 31, 2019, with an original closing date of December 6, 2019. The listing shows an award ceiling of 0, which typically reflects that the maximum award amount was not captured in this summary field or was to be specified in the full solicitation materials rather than implying no funding.

Overall, the FY19 CPMRP IIRA is best understood as a mechanism for supporting impactful, non-clinical-trial research that targets the critical window when pain shifts from short-term to long-term, with the long-range goal of preventing chronic pain before it becomes entrenched and harder to treat.

  • The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Chronic Pain Management Research Program, Investigator-Initiated Research Award" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
  • This funding opportunity was created on Jul 31, 2019.
  • Applicants must submit their applications by Dec 06, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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