Opportunity Information: Apply for PA 21 259
The PHS 2021-2 Omnibus Solicitation is a federal SBIR grant opportunity issued jointly by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA). It is designed to fund early-stage research and development led by eligible United States small businesses that can bring strong scientific capability and technical expertise to priorities within NIH, CDC, and FDA mission areas. In practical terms, this is a broad "parent" solicitation meant to capture a wide range of innovative, product-oriented R and D concepts, as long as the proposed work aligns with one of the participating components and fits within the specific topics described in the companion topic document (the PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA).
The funding instrument is an SBIR grant using the R43 and R44 mechanisms. These mechanisms generally reflect phased development pathways used in SBIR: Phase I (R43) supports feasibility and proof-of-concept R and D, while Phase II (R44) supports further development, refinement, and steps that move an innovation closer to commercialization or practical deployment. The solicitation is categorized as discretionary funding and spans a wide set of public-purpose areas reflected in the activity category listing (including health, environment, food and nutrition, education, and related social services domains), which signals that the agencies intend to support innovations that can materially improve public health outcomes, biomedical research, disease prevention, diagnostics, therapeutics, health technologies, and related regulatory science needs.
A central rule of this specific parent announcement is that clinical trials are not allowed. That means applicants must shape their projects so that the proposed research does not meet the definition of a clinical trial under NIH policy (for example, it cannot prospectively assign human participants to an intervention to evaluate effects on health-related outcomes). Small businesses can still propose substantial non-clinical and preclinical development work, tool building, platform development, laboratory validation, analytical studies, benchtop testing, animal studies (when appropriate and permitted), engineering work, and other R and D activities that strengthen feasibility and readiness for later-stage translation. If a company intends to run a clinical trial, it would need to look for a different FOA that explicitly allows clinical trials rather than using this one.
Eligibility is focused on U.S. small businesses. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply under this announcement. However, the notice indicates that "foreign components" may be allowed as defined in the NIH Grants Policy Statement, which typically refers to discrete elements of a project carried out outside the United States under specific conditions and approvals (for instance, a specialized assay performed by a unique overseas laboratory when strongly justified). Even when foreign components are allowable, the applicant organization must still be an eligible U.S. small business, and the application must follow all applicable policy requirements governing such components.
The opportunity is identified by Funding Opportunity Number PA-21-259, with NIH listed as the primary agency name in the source data, reflecting NIH's common role as the central grants management body for these omnibus SBIR solicitations, even when CDC and FDA components participate. The original closing date shown in the source data is 2022-04-05, and the opportunity record creation date is 2021-07-08. The listing also includes a large set of CFDA numbers (now often referenced as Assistance Listing numbers), which indicates that multiple NIH institutes and centers, along with CDC and FDA programs, may support awards under their respective appropriations and authorities, depending on topic alignment and available funds.
Overall, this solicitation functions as a wide-entry SBIR pathway for U.S. small businesses pursuing innovative R and D that fits NIH, CDC, or FDA priorities, provided the work is non-clinical-trial in nature. Applicants are expected to match their proposed aims to the published topic areas, demonstrate strong technical merit and feasibility, and position the project for practical impact and eventual commercialization or deployment consistent with SBIR program goals.Apply for PA 21 259
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068, 93.070, 93.073, 93.083, 93.084, 93.103, 93.113, 93.121, 93.136, 93.172, 93.173, 93.213, 93.233, 93.242, 93.262, 93.273, 93.279, 93.286, 93.307, 93.316, 93.326, 93.350, 93.351, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2021-07-08.
- Applicants must submit their applications by 2022-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 21 259) also looked into and applied for these:
| Funding Opportunity |
|---|
| PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 21 260 Funding Number: PA 21 260 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center and Database (UM1 Clinical Trial Not Allowed) Apply for RFA HG 21 037 Funding Number: RFA HG 21 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Clinical Trial Not Allowed Apply for RFA HG 21 036 Funding Number: RFA HG 21 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Apply for PA 21 345 Funding Number: PA 21 345 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) Apply for PAR 22 073 Funding Number: PAR 22 073 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 22 105 Funding Number: PAR 22 105 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 22 177 Funding Number: PA 22 177 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 22 178 Funding Number: PA 22 178 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 22 176 Funding Number: PA 22 176 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| Maternal Health Research Centers of Excellence Data Innovation and Coordinating Hub/Resource Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 23 036 Funding Number: RFA HD 23 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence Implementation Science Hub/Resource Center (U24 Clinical Trial Optional) Apply for RFA HD 23 037 Funding Number: RFA HD 23 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence (U54 Clinical Trial Optional) Apply for RFA HD 23 035 Funding Number: RFA HD 23 035 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $17,500,000 |
| Open Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 017 Funding Number: RFA OD 22 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Laboratory Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 016 Funding Number: RFA OD 22 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Coordinating Center (U2C) (Clinical Trial Not Allowed) Apply for RFA OD 22 021 Funding Number: RFA OD 22 021 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 019 Funding Number: RFA OD 22 019 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Data Analysis Center (U24) Clinical Trial Not Allowed Apply for RFA OD 22 022 Funding Number: RFA OD 22 022 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy and Pediatric Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 018 Funding Number: RFA OD 22 018 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Measurement Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 020 Funding Number: RFA OD 22 020 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 23 048 Funding Number: PA 23 048 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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