Opportunity Information: Apply for RFA RM 18 036
The funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01 Clinical Trial Not Allowed)" is a National Institutes of Health (NIH) cooperative agreement announcement issued under the Department of Health and Human Services. It sits within the NIH Common Fund program called Accelerating Translation of Glycoscience Integration and Accessibility, which is focused on making glycoscience easier to do, cheaper to adopt, and more practical for the broader biomedical research community. The core idea is to lower the barriers that have traditionally kept many laboratories from working with carbohydrates and glycans, so researchers who do not specialize in glycoscience can still study glycan structure and function in ways that meaningfully advance understanding of health and disease.
The scientific emphasis is on creating genuinely new or substantially improved tools, reagents, and technologies that help investigators identify glycans, track them in biological settings, manipulate them experimentally, and analyze their interactions with biological binding partners in order to determine function. In practical terms, the solicitation is interested in capabilities that make it easier to detect and characterize glycan structures, observe where specific glycans are located or how they change over time, perturb glycan pathways or glycan mediated interactions in controlled ways, and connect glycan features to biological outcomes. A central theme is usability and accessibility: the resulting methods should be easier to adopt than traditional glycoscience approaches, which often require specialized expertise, expensive equipment, or complex workflows. Projects can build on and interface with existing technologies, but the expectation is that the proposed work pushes beyond incremental tweaks by delivering tools that are more robust, more broadly usable, and better positioned for real uptake by non-specialist biomedical labs.
Because the goal is widespread adoption, applicants are expected to think beyond proof-of-concept demonstrations. Where applicable, proposals should address scale-up considerations so that any instrumentation, platforms, or workflows can be made broadly accessible and cost-effective for end users. Another practical requirement is data compatibility: tools that generate data should do so in a way that supports integration with existing databases, enabling discovery, comparison, and reuse across the community rather than creating isolated datasets that cannot be readily combined with other resources. This focus on interoperability signals that the program is not only interested in new experimental capabilities, but also in ensuring the outputs can plug into the broader glycoscience and biomedical data ecosystem.
The award mechanism is a U01 cooperative agreement, meaning NIH program staff will likely have substantial scientific and administrative involvement during the project compared with a standard grant. The announcement explicitly states "Clinical Trial Not Allowed," so applications should be clearly positioned as technology and tool development rather than clinical intervention studies. The opportunity is categorized under health research (CFDA 93.310) and is open to a wide range of applicants, including federal recognized tribal governments and organizations, state and local governments, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), public housing authorities/Indian housing authorities, for-profit organizations other than small businesses, and small businesses, with additional eligibility details referenced in the full announcement.
From the published opportunity details, the funding opportunity number is RFA-RM-18-036. It was created on August 10, 2018, with an original closing date of October 29, 2018. The expected number of awards was 5, and the listed award ceiling is $320,000. Finally, the announcement notes a closely related companion solicitation, RFA-RM-18-037, which is aimed more specifically at adapting existing technologies to simplify them and improve accessibility. In contrast, this RFA-RM-18-036 announcement is oriented toward developing new or more robust tools and technologies, while still emphasizing practical usability, cost, scale, and compatibility with existing data infrastructure.Apply for RFA RM 18 036
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Aug 10, 2018.
- Applicants must submit their applications by Oct 29, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $320,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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