Opportunity Information: Apply for RFA DE 19 006
The National Dental Practice-Based Research Network: Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Optional), RFA-DE-19-006, is a funding opportunity from the National Institute of Dental and Craniofacial Research (NIDCR) within the NIH (U.S. Department of Health and Human Services). Its purpose is to support investigator-initiated oral health research studies that take place in real-world dental practice settings by leveraging the existing National Dental Practice-Based Research Network (DPBRN). The emphasis is on generating practical, clinically relevant evidence that matters to dental practitioners and their patients, while also speeding up how quickly research findings can be adopted in everyday care.
A key feature of this opportunity is that it is built around a national network infrastructure that NIDCR is sustaining through two companion awards: one for the DPBRN Administrative and Resource Center (RFA-DE-19-001) and one for the DPBRN Coordinating Center (RFA-DE-19-002). Those two centers provide the operational backbone for the network, helping studies run efficiently across participating practices. Applicants to RFA-DE-19-006 are not being asked to build the network itself; instead, they propose a specific clinical observational study or clinical trial that will use the DPBRN’s established people, processes, and systems to plan and carry out the research.
The award mechanism is a milestone-driven UG3/UH3 cooperative agreement, which is designed to support a two-stage path from planning into implementation. The UG3 phase is the planning stage, where the project team is expected to complete defined preparatory work and hit pre-specified milestones needed to responsibly and feasibly launch the study. If that planning phase is successful, the project can transition into the UH3 phase, which supports full study implementation. The total combined project period across UG3 plus UH3 can be up to six years, but the move from UG3 to UH3 is not automatic. Transition depends on an administrative review that considers whether UG3 milestones were met, whether the DPBRN remains an appropriate and effective venue for the proposed research, how well the project aligns with NIDCR program priorities at the time of transition, and whether funds are available.
Because this is a cooperative agreement, the relationship between the awardee and the funder is more collaborative than in a standard grant. In practice, that typically means NIDCR expects active involvement in the oversight of milestones and study progress, with an emphasis on accountability and readiness before a large implementation phase begins. The announcement also notes that clinical trials are optional, meaning applications may propose either clinical trials or observational clinical studies, so long as they are designed for conduct within the DPBRN environment.
In terms of who can apply, eligibility is broad and includes many organization types: federal recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and other entities as described in the FOA’s additional eligibility guidance. The funding instrument type is a cooperative agreement, and the activity category is health. The CFDA (now commonly referred to as Assistance Listing) number associated with this opportunity is 93.121. The posting lists an expected number of awards of three, and it shows an award ceiling of 0, which generally indicates that applicants should rely on the FOA’s detailed budget instructions and any NIH policy constraints rather than a single posted maximum cap.
Important administrative details from the source listing include a creation date of October 5, 2018, and an original closing date of February 11, 2019. While those dates mean this specific cycle is historical, the structure and intent provide a clear picture of NIDCR’s approach: use a national practice-based network to reduce friction in launching multisite dental studies, prioritize questions that arise in routine dental care, and produce evidence that is directly usable by clinicians while strengthening the pipeline from research to practice.Apply for RFA DE 19 006
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "National Dental Practice-Based Research Network: Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on Oct 05, 2018.
- Applicants must submit their applications by Feb 11, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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