Opportunity Information: Apply for PAR 23 059
The National Cancer Institute (NCI) is soliciting investigator-initiated Program Project (P01) grant applications under Funding Opportunity Announcement PAR 23-059, titled "National Cancer Institute Program Project Applications for the Years 2023, 2024, and 2025 (P01 Clinical Trial Optional)." This opportunity supports large, multi-project research programs that bring together several related studies under one coordinated umbrella. The goal is to fund integrated, theme-driven programs where multiple investigators and projects work in a deliberately connected way to make progress on an overarching cancer research objective, rather than operating as a loose collection of independent studies.
Scientifically, the FOA is broad and flexible. Applicants may propose programs in essentially any major area of cancer research, including cancer biology, prevention, diagnosis, treatment, and cancer control. NCI indicates that basic, translational, clinical, and population-based approaches are all responsive, and the "clinical trial optional" designation means a proposed program may include clinical trials, but it is not required to do so. In practice, this allows applicants to build programs that range from mechanistic lab science to translational pipelines to human studies, as long as the overall package is coherent and justified by a shared theme and a clear strategy for synergy among components.
Structurally, every application must include at least three distinct research projects plus an Administrative Core. The expectation is that the projects are scientifically interrelated and organized around a common central theme, focus, and/or overall objective. The Administrative Core is required and is typically used to manage leadership, governance, communication, coordination across projects and shared resources, tracking of milestones, and other program-level functions that make the whole program operate effectively as a unified effort. While the notice highlights the Administrative Core as mandatory, applicants commonly use additional cores or shared resources when they are essential to multiple projects, but the key baseline requirement in this FOA is the minimum of three projects and the Administrative Core, with clear integration across the portfolio.
Eligibility is broad and includes many types of U.S.-based organizations. Eligible applicants listed in the source data include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
The funding instrument is a grant, and the activity area is categorized under Education and Health, with CFDA number 93.393, and the sponsoring agency is the National Institutes of Health (NIH) through NCI. The opportunity is discretionary. The FOA record shows an original closing date of 2026-05-07, and the posting (creation) date is 2022-12-14. The award ceiling, expected number of awards, and similar numerical details are not provided in the supplied source data, which usually means applicants need to consult the full FOA and NIH policy pages for budgeting expectations, project period limits, and any institute-specific guidance.
There are important limits on non-U.S. participation. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply directly, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" are allowed as defined by the NIH Grants Policy Statement. In practical terms, this generally means a U.S.-based applicant organization can include certain well-justified international elements of work or collaborations when they meet NIH definitions and requirements, but the primary applicant organization itself must be eligible and domestic under the FOA rules.
Overall, this FOA is designed for teams that can articulate a strong, unifying cancer research theme and demonstrate why a coordinated program structure will achieve more than separate standalone grants. The required multi-project format and administrative infrastructure are meant to support complex, collaborative research programs that are integrated across disciplines and methods, while still allowing flexibility in scientific focus across the cancer research continuum.Apply for PAR 23 059
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "National Cancer Institute Program Project Applications for the Years 2023, 2024, and 2025 (P01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
- This funding opportunity was created on 2022-12-14.
- Applicants must submit their applications by 2026-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Co-infection and Cancer (R01 Clinical Trial Not Allowed) Apply for PAR 23 055 Funding Number: PAR 23 055 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Co-infection and Cancer (R21 Clinical Trial Not Allowed) Apply for PAR 23 056 Funding Number: PAR 23 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Mechanisms and Targets at the Intersection of HIV and Substance Use (R21 Clinical Trials Not Allowed) Apply for RFA DA 24 014 Funding Number: RFA DA 24 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Mechanisms and Targets at the Intersection of HIV and Substance Use (R01 Clinical Trials Not Allowed) Apply for RFA DA 24 013 Funding Number: RFA DA 24 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R61/R33 Clinical Trial Required) Apply for RFA DA 24 011 Funding Number: RFA DA 24 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R01 Clinical Trial Required) Apply for RFA DA 24 012 Funding Number: RFA DA 24 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional) Apply for RFA CA 23 014 Funding Number: RFA CA 23 014 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 23 016 Funding Number: RFA CA 23 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) Apply for RFA CA 23 015 Funding Number: RFA CA 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional) Apply for RFA CA 23 017 Funding Number: RFA CA 23 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Translational Centers for Microphysiological Systems (TraCe MPS) (U2C Clinical Trials Not Allowed) Apply for RFA TR 23 001 Funding Number: RFA TR 23 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Core "Center of Excellence" Grant Program (P30 Clinical Trial Optional) Apply for PAR 23 049 Funding Number: PAR 23 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed) Apply for PAR 23 088 Funding Number: PAR 23 088 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| NIDA Program Project Grant Applications (P01 Clinical Trial Optional) Apply for PAR 23 064 Funding Number: PAR 23 064 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional) Apply for PAR 23 076 Funding Number: PAR 23 076 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Required) Apply for PAR 23 107 Funding Number: PAR 23 107 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Not Allowed) Apply for PAR 23 108 Funding Number: PAR 23 108 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional) Apply for RFA DA 24 037 Funding Number: RFA DA 24 037 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Education Activities for Responsible Analyses of Complex, Large-Scale Data (R25- Clinical Trial Not Allowed) Apply for RFA DA 24 027 Funding Number: RFA DA 24 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 Clinical Trials Not Allowed) Apply for RFA DA 24 009 Funding Number: RFA DA 24 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
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