Opportunity Information: Apply for RFA AT 24 002
The funding opportunity "Limited Competition: NIH-DoD-VA Pain Management Collaboratory - Coordinating Center (U24 Clinical Trial Not Allowed)" (RFA-AT-24-002) is a National Institutes of Health (NIH) cooperative agreement intended to continue support for a single Coordinating Center that provides national leadership for the NIH-DoD-VA Pain Management Collaboratory (PMC). The PMC focuses on advancing evidence-based, non-pharmacological approaches to pain management for U.S. veterans, active-duty military personnel, and/or their family members, with an emphasis on carrying out research in real-world health care delivery settings connected to the Department of Veterans Affairs (VA) and the Department of Defense (DoD). As a U24 cooperative agreement, the award is structured for substantial NIH involvement in the program, and it is explicitly designated as "Clinical Trial Not Allowed," meaning the Coordinating Center itself is not proposing or running an independent clinical trial as its primary activity.
At its core, the Coordinating Center is meant to function as the operational and scientific backbone of the broader collaboratory. The NOFO lays out three major responsibilities. First, the Coordinating Center must develop, adapt, and promote technical and policy guidance and best practices that make it easier to conduct high-quality research in partnership with health care systems serving veterans and military communities. This includes practical guidance on common barriers in embedded or pragmatic research, such as working within clinical workflows, handling multi-site operational differences, aligning research procedures with health system policies, and addressing issues that come up when research is tightly integrated into routine care. Second, the Coordinating Center must collaborate directly with the PMC Demonstration Project teams by providing hands-on support across study design and implementation. This support is geared toward helping demonstration teams develop and execute pragmatic trial protocols within participating health care settings, including assistance with methodological planning, operational troubleshooting, and harmonizing approaches across projects when appropriate. Third, the Coordinating Center is responsible for broad dissemination of the collaboratory's endorsed policies, best practices, and lessons learned from the demonstration projects so that methods and tools developed through PMC can be used by other researchers and health systems interested in implementing non-pharmacological pain management research in routine care environments.
Beyond the technical and scientific support functions, the Coordinating Center also serves as the central administrative and coordination hub for the PMC program. A key part of that role is supporting the PMC Steering Committee and its subcommittees, which typically involves organizing meetings, maintaining documentation, facilitating cross-project communication, and ensuring consistent processes for decision-making and collaborative work. In other words, the Coordinating Center is expected to keep the collaboratory functioning as a cohesive national program rather than a collection of unrelated projects, while also strengthening the infrastructure and shared playbook for doing embedded pain management research across NIH-DoD-VA contexts.
Eligibility is broad across many U.S.-based organization types, including state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations; public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses, among others. The NOFO also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and U.S. territories or possessions. However, the opportunity is restricted to domestic applicants: non-U.S. entities (foreign organizations and foreign institutions) cannot apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed.
Key administrative details included in the source information are that this is a discretionary funding opportunity under a cooperative agreement mechanism, in the health and education activity category, associated with CFDA numbers 93.213, 93.273, and 93.361. The listed award ceiling is $1,300,000, and the original application closing date was August 31, 2023 (with the record created June 28, 2023). Overall, the opportunity is designed to sustain a centralized coordinating infrastructure that improves how pragmatic, health-system-partnered research on non-drug pain management is designed, implemented, and shared across NIH, DoD, and VA settings, ultimately supporting scalable improvements in pain care for service members, veterans, and their families.Apply for RFA AT 24 002
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Limited Competition: NIH-DoD-VA Pain Management Collaboratory - Coordinating Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.361.
- This funding opportunity was created on 2023-06-28.
- Applicants must submit their applications by 2023-08-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,300,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Limited Competition: NIH-DoD-VA Pain Management Collaboratory - Coordinating Center (U24 Clinical Trial Not Allowed) (RFA-AT-24-002)
What is this funding opportunity?
This opportunity is a National Institutes of Health (NIH) cooperative agreement to continue support for a single Coordinating Center for the NIH-DoD-VA Pain Management Collaboratory (PMC). The Coordinating Center is intended to provide national leadership and serve as the operational and scientific backbone of the collaboratory.
What is the program mechanism and what does it imply?
The mechanism is a U24 cooperative agreement. A cooperative agreement indicates substantial NIH involvement in the program, meaning NIH is expected to participate actively in the oversight and direction of the funded activities compared with a standard grant.
Is a clinical trial allowed under this award?
No. The opportunity is explicitly designated as "U24 Clinical Trial Not Allowed," which means the Coordinating Center itself is not proposing or running an independent clinical trial as its primary activity.
What is the Pain Management Collaboratory (PMC) focused on?
PMC focuses on advancing evidence-based, non-pharmacological approaches to pain management for U.S. veterans, active-duty military personnel, and/or their family members. It emphasizes carrying out research in real-world health care delivery settings connected to the Department of Veterans Affairs (VA) and the Department of Defense (DoD).
What are the Coordinating Center's main responsibilities?
The Coordinating Center has three major responsibilities described in the opportunity:
- Develop, adapt, and promote technical and policy guidance and best practices to make it easier to conduct high-quality research in partnership with VA- and DoD-connected health care systems.
- Collaborate directly with PMC Demonstration Project teams by providing hands-on support across study design and implementation (including methodological planning, operational troubleshooting, and harmonizing approaches across projects when appropriate).
- Disseminate endorsed policies, best practices, and lessons learned from the demonstration projects so PMC methods and tools can be used by other researchers and health systems.
What kinds of barriers or practical issues is the Coordinating Center expected to address?
The opportunity highlights common barriers in embedded or pragmatic research, including working within clinical workflows, handling multi-site operational differences, aligning research procedures with health system policies, and addressing issues that arise when research is integrated into routine care.
How does the Coordinating Center support PMC Demonstration Projects?
The Coordinating Center provides hands-on support to demonstration teams to help them develop and execute pragmatic trial protocols within participating health care settings. This includes help with study design, implementation planning, troubleshooting operational challenges, and aligning or harmonizing approaches across projects when appropriate.
What does "real-world health care delivery settings" mean in this context?
In this opportunity, it refers to research conducted in routine care environments connected to VA and DoD systems, where studies must fit within existing clinical workflows and operational realities rather than being run solely as tightly controlled research settings.
What is meant by "non-pharmacological approaches to pain management"?
The collaboratory is centered on non-drug approaches to pain management. The provided information does not list specific interventions, but it clearly distinguishes the focus as non-pharmacological (non-medication) strategies.
What is the Coordinating Center's role in dissemination?
The Coordinating Center is responsible for broad dissemination of the collaboratory's endorsed policies, best practices, and lessons learned so that tools and methods developed through PMC can be adopted by other researchers and health systems interested in conducting similar non-pharmacological pain management research in routine care environments.
What administrative or coordination functions are expected of the Coordinating Center?
The Coordinating Center serves as the central administrative and coordination hub for PMC. It supports the PMC Steering Committee and its subcommittees by organizing meetings, maintaining documentation, facilitating cross-project communication, and supporting consistent processes for decision-making and collaborative work.
What is the purpose of having a single Coordinating Center?
The opportunity is designed to sustain a centralized coordinating infrastructure that keeps PMC functioning as a cohesive national program rather than a set of unrelated projects, while strengthening shared infrastructure and a common playbook for embedded pain management research across NIH, DoD, and VA contexts.
Who can apply?
Eligibility is broad across many U.S.-based organization types, including (as listed in the opportunity summary): state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations; public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses, among others.
Are specific institution categories highlighted as eligible?
Yes. The opportunity highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also notes faith-based or community-based organizations and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. The opportunity is restricted to domestic applicants. Non-U.S. entities (foreign organizations and foreign institutions) cannot apply.
Can a U.S. organization include a non-U.S. component in its application?
No. Non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
What agencies are involved in the collaboratory supported by this award?
The collaboratory is described as the NIH-DoD-VA Pain Management Collaboratory, reflecting involvement and collaboration across the National Institutes of Health (NIH), the Department of Defense (DoD), and the Department of Veterans Affairs (VA).
What is the award ceiling?
The listed award ceiling is $1,300,000.
What is the application closing date shown in the provided information?
The original application closing date listed is August 31, 2023. The record is noted as created on June 28, 2023.
What type of funding opportunity is this described as?
It is described as a discretionary funding opportunity under a cooperative agreement mechanism, in the health and education activity category.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.213, 93.273, and 93.361.
What is the overarching goal of supporting this Coordinating Center?
The goal is to sustain a centralized coordinating infrastructure that improves how pragmatic, health-system-partnered research on non-drug pain management is designed, implemented, and shared across NIH, DoD, and VA settings, ultimately supporting scalable improvements in pain care for service members, veterans, and their families.
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