Opportunity Information: Apply for RFA DP 25 126
The Centers for Disease Control and Prevention (CDC) is offering a competitive supplemental funding opportunity for its existing Prevention Research Centers (PRCs) to carry out 2025 Special Interest Projects (SIPs) under a cooperative agreement. This Notice of Funding Opportunity (NOFO), titled "Health Promotion and Disease Prevention Research Centers: 2025 Special Interest Project Competitive Supplements (SIPS)," is designed to add targeted resources to already-funded PRCs so they can take on specific, CDC-prioritized applied research projects. The overall goal is practical: generate strong, real-world evidence that public health programs and partners can actually use to prevent disease, reduce risk, and improve health outcomes tied to the leading causes of illness, disability, and death in the United States. The emphasis is on applied health promotion and disease prevention research conducted in real-world settings, with an expectation that projects will move beyond theory into identifying, designing, testing, assessing, evaluating, disseminating, and translating interventions and tools. Interventions can include programs, practices, policies, strategies, or other resources intended to support prevention and health improvement.
This opportunity is not open to the general public or to new institutions seeking to become PRCs. Eligibility is limited to institutions that are already approved for funding under CDC NOFO RFA-DP-24-004 (Health Promotion and Disease Prevention Research Centers). In other words, an applicant must already be one of the CDC-funded PRCs to apply for these SIP supplements. There is also a key administrative requirement: on the SF424 (R&R) application for the SIP, the institution legal name, EIN, and UEI (fields 8a, 8b, and 8c) must exactly match the entity information shown on the Notice of Award for the institution funded under RFA-DP-24-004. The NOFO notes that additional, SIP-specific eligibility conditions may apply depending on the particular project topic, meaning a PRC may be eligible for some SIPs but not necessarily all of them.
The NOFO includes seven SIP topic areas, reflecting a mix of cancer prevention and control, screening improvement, chronic disease lifestyle intervention implementation, immunization promotion in early childhood settings, and overdose prevention and treatment research. The seven SIPs are: (1) validating survey questions on prostate cancer screening, including PSA testing and shared decision-making; (2) identifying prostate cancer active surveillance using electronic health record data; (3) generating practice-based evidence on approaches for accurate identification and appropriate selection of individuals for lung cancer screening; (4) the Lifestyle Change Implementation Research Network (LCIRN), focused on implementation research for lifestyle change interventions; (5) assessing the potential of early childcare and education (ECE) centers to promote childhood vaccines and RSV prevention products; (6) the Overdose Prevention and Treatment Research Network (OPTRN), supporting research linked to overdose prevention and treatment; and (7) scaling what works within the National Comprehensive Cancer Control Program, which points to expanding proven approaches across comprehensive cancer control efforts. Collectively, these topics signal CDC interest in improving measurement tools (like survey questions), leveraging clinical data systems (like EHRs), strengthening screening pathways, and translating evidence-based prevention and treatment strategies into routine practice at scale.
From a funding and logistics standpoint, this is a discretionary funding opportunity using the cooperative agreement mechanism, which typically means CDC expects substantial involvement in the funded work (for example, coordination, technical assistance, or collaboration on project direction, consistent with cooperative agreement norms). The Funding Opportunity Number is RFA-DP-25-126 and it is associated with CFDA (Assistance Listing) 93.135. The original application closing date is February 28, 2025. CDC lists an award ceiling of $5,902,000 and expects to make 12 awards under this announcement, indicating that not every PRC will receive a supplement and that awards will be competitive across the eligible centers and SIP topics.
The universe of eligible applicants is the 20 institutions currently funded as PRCs under RFA-DP-24-004. These are Emory University; Georgia State University; Harvard School of Public Health; Morehouse School of Medicine; New York University School of Medicine; San Diego State University; University of Arizona; University of Arkansas for Medical Sciences; University of California, San Francisco; University of Iowa; University of Massachusetts Medical School Worcester; University of Michigan at Ann Arbor; University of Minnesota; University of North Carolina at Chapel Hill; University of Pennsylvania; University of Pittsburgh; University of Rochester; University of South Carolina at Columbia; University of Utah; and University of Wisconsin-Madison. Each of these institutions holds a U48 cooperative agreement award as a CDC PRC, and only these CDC-approved PRC awardees (with matching entity identifiers) may apply for the SIP supplemental funding described in this NOFO.Apply for RFA DP 25 126
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Health Promotion and Disease Prevention Research Centers: 2025 Special Interest Project Competitive Supplements (SIPS)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.135.
- This funding opportunity was created on 2024-12-12.
- Applicants must submit their applications by 2025-02-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,902,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: Others.
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