Opportunity Information: Apply for 2025 NIST SBIR 02

The FY 2025 NIST Small Business Innovation Research (SBIR) Program Phase II opportunity is a follow-on funding competition run by the National Institute of Standards and Technology (NIST) for small businesses that previously received a NIST SBIR Phase I award in Fiscal Year 2024. The central purpose of this Phase II notice of funding opportunity (NOFO) is to help those Phase I performers continue and expand their earlier work into a more advanced development effort aimed at producing something that can realistically move beyond research and into use. NIST frames that end goal as developing a viable product or service and/or creating a standard that can be introduced into the commercial marketplace, meaning the project should be positioned for practical adoption, commercialization, and measurable impact rather than remaining at the proof-of-concept stage.

Eligibility is tightly restricted. Only FY 2024 NIST SBIR Phase I award recipients may apply to this Phase II NOFO, and proposals are expected to be directly tied to the Phase I project line of work. The applicant must meet the definition of a Small Business Concern for Research/Research and Development (R/R&D) purposes, as described in Section 1.05 of the NOFO, and that status must be true at the time of award (not just at the time of application). The notice also places a specific requirement on the principal investigator (PI): the PI must have primary employment with the small business at the time of award and throughout the period of performance. In practical terms, NIST defines primary employment as the PI spending more than half of their working time with the small business, and it explicitly notes that this arrangement rules out full-time employment with another organization while serving as PI on the project.

From an administrative and funding mechanics standpoint, this opportunity is categorized as discretionary funding and uses a cooperative agreement as the funding instrument. A cooperative agreement typically indicates a more collaborative relationship between the recipient and the federal agency than a standard grant, often with some level of federal involvement or coordination during the project. The program sits under the Science and Technology and other Research and Development activity category and is associated with CFDA number 11.620. The issuing agency is NIST, and the opportunity is listed under Funding Opportunity Number 2025 NIST SBIR 02, with a recorded creation date of April 16, 2025. The original closing date provided is June 14, 2025, which is the key deadline applicants should plan around for submission.

While the summary data provided does not include an award ceiling or the expected number of awards, the intent is clear: NIST is looking to fund Phase II efforts that build on validated Phase I results and push toward deliverables with commercial or standards-based outcomes. For applicants, the most important takeaways are that this is not an open solicitation to new SBIR applicants, the proposal must be a continuation of an FY 2024 NIST Phase I project, the business must remain SBIR-eligible at award time, and the PI must be primarily employed by the small business for the duration of the work.

  • The National Institute of Standards and Technology in the science and technology and other research and development sector is offering a public funding opportunity titled "FY 2025 NIST Small Business Innovation Research Program Phase II" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 11.620.
  • This funding opportunity was created on 2025-04-16.
  • Applicants must submit their applications by 2025-06-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Others.
Apply for 2025 NIST SBIR 02

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:

FY 2025 NIST SBIR Phase II (Follow-on to FY 2024 Phase I) - FAQs

1) What is the FY 2025 NIST SBIR Phase II opportunity?

This is a follow-on funding competition from the National Institute of Standards and Technology (NIST) for small businesses that previously received a NIST SBIR Phase I award in Fiscal Year (FY) 2024. The Phase II effort is meant to continue and expand the Phase I work into a more advanced development project.

2) What is the main purpose of this Phase II NOFO?

The central purpose is to help FY 2024 Phase I performers move beyond proof-of-concept and into a development effort that can realistically transition into use. NIST describes the end goal as developing a viable product or service and/or creating a standard that can be introduced into the commercial marketplace, with practical adoption, commercialization, and measurable impact.

3) Is this an open SBIR solicitation for new applicants?

No. Eligibility is tightly restricted. Only businesses that received a FY 2024 NIST SBIR Phase I award may apply.

4) Who is eligible to apply?

Only FY 2024 NIST SBIR Phase I award recipients may apply to this Phase II Notice of Funding Opportunity (NOFO).

5) Does the Phase II proposal have to relate to the Phase I project?

Yes. Proposals are expected to be directly tied to the Phase I project line of work and to build on validated Phase I results.

6) What type of organization must the applicant be?

The applicant must meet the definition of a Small Business Concern for Research/Research and Development (R/R&D) purposes, as described in Section 1.05 of the NOFO.

7) When must the business meet the small business eligibility definition?

The small business eligibility status must be true at the time of award, not just at the time of application.

8) What are the principal investigator (PI) employment requirements?

The PI must have primary employment with the small business at the time of award and throughout the entire period of performance.

9) How does NIST define "primary employment" for the PI?

NIST defines primary employment as the PI spending more than half of their working time with the small business.

10) Can the PI be employed full-time by another organization while serving as PI?

No. NIST explicitly notes that the primary employment requirement rules out full-time employment with another organization while serving as PI on the project.

11) What kind of funding is this (discretionary or mandatory)?

This opportunity is categorized as discretionary funding.

12) What is the funding instrument for this opportunity?

The funding instrument is a cooperative agreement.

13) What does it mean that the award instrument is a cooperative agreement?

A cooperative agreement typically indicates a more collaborative relationship between the recipient and the federal agency than a standard grant, often with some level of federal involvement or coordination during the project.

14) What is the relevant activity category for this program?

The program sits under the Science and Technology and other Research and Development activity category.

15) What is the CFDA number associated with this opportunity?

The opportunity is associated with CFDA number 11.620.

16) Which federal agency is issuing this funding opportunity?

The issuing agency is the National Institute of Standards and Technology (NIST).

17) What is the Funding Opportunity Number?

The Funding Opportunity Number is 2025 NIST SBIR 02.

18) What is the posted creation date for the opportunity listing?

The recorded creation date is April 16, 2025.

19) What is the application deadline?

The original closing date provided is June 14, 2025.

20) Are award amounts (ceiling) or the expected number of awards provided in the summary?

No. The summary data provided does not include an award ceiling or the expected number of awards.

21) What kinds of outcomes is NIST looking for in Phase II?

NIST is looking for Phase II efforts that build on validated Phase I results and push toward deliverables with commercial or standards-based outcomes, such as a viable product or service and/or a standard suitable for introduction into the commercial marketplace.

22) What is the most important eligibility takeaway for potential applicants?

This is not open to new SBIR applicants; it is limited to FY 2024 NIST SBIR Phase I award recipients. The Phase II proposal must continue that Phase I work, the business must remain SBIR-eligible at award time, and the PI must be primarily employed by the small business for the duration of the project.

Browse more opportunities from the same agency: National Institute of Standards and Technology

Browse more opportunities from the same category: Science and Technology and other Research and Development

Next opportunity: Senior Medicare Patrol (SMP) Resource Center

Previous opportunity: FY 2025 Assistance for Local Emergency Response Training (ALERT) Grant

Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for 2025 NIST SBIR 02

 

Applicants also applied for:

Applicants who have applied for this opportunity (2025 NIST SBIR 02) also looked into and applied for these:

Funding Opportunity
Incorporating Human Behavior in Epidemiological Models Apply for 25 538

Funding Number: 25 538
Agency: U.S. National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Responsible Design, Development, and Deployment of Technologies Apply for 25 536

Funding Number: 25 536
Agency: U.S. National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $1,500,000
Alzheimer’s Research Program Transforming Research Award Apply for HT942525AZRPTRRA

Funding Number: HT942525AZRPTRRA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DOD Amyotrophic Lateral Sclerosis, Therapeutic Development Award Apply for HT942525ALSRPTDA

Funding Number: HT942525ALSRPTDA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DOD Amyotrophic Lateral Sclerosis, Therapeutic Idea Award Apply for HT942525ALSRPTIA

Funding Number: HT942525ALSRPTIA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Alzheimer’s Research Program Transforming Care Award Apply for HT942525AZRPTRCA

Funding Number: HT942525AZRPTRCA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DOD Amyotrophic Lateral Sclerosis, Clinical Outcomes and Biomarkers Award Apply for HT942525ALSRPCOBA

Funding Number: HT942525ALSRPCOBA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award Apply for HT942525ALSRPPCTA

Funding Number: HT942525ALSRPPCTA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Alzheimer’s Research Program Transforming Diagnosis Award Apply for HT942525AZRPTRDA

Funding Number: HT942525AZRPTRDA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Breast Cancer Clinical Research Extension Award Apply for HT942525BCRPCREA

Funding Number: HT942525BCRPCREA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Breast Cancer Breakthrough Award Levels 1 and 2 Apply for HT942525BCRPBTA12

Funding Number: HT942525BCRPBTA12
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Breast Cancer Breakthrough Award Level 3 Apply for HT942525BCRPBTA3

Funding Number: HT942525BCRPBTA3
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Breast Cancer Era of Hope Scholar Award Apply for HT942525BCRPEOHS

Funding Number: HT942525BCRPEOHS
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
University Day Apply for FA865122S0001 CALL05

Funding Number: FA865122S0001 CALL05
Agency: Munitions Directorate
Category: Science and Technology and other Research and Development
Funding Amount: $100,000
DOD Duchenne Muscular Dystrophy, Clinical/Translational Research Award Apply for HT942525DMDRPCTRA

Funding Number: HT942525DMDRPCTRA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Rare Cancers, Concept Award Apply for HT942525RCRPCA

Funding Number: HT942525RCRPCA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Regional Alliances and Multistakeholder Partnerships to Stimulate (RAMPS) Cybersecurity Education and Workforce Development Apply for 2025 NIST RAMPS 01

Funding Number: 2025 NIST RAMPS 01
Agency: National Institute of Standards and Technology
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Rare Cancers, Resource and Community Development Award Apply for HT942525RCRPRCDA

Funding Number: HT942525RCRPRCDA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DoD Rare Cancers, Idea Development Award Apply for HT942525RCRPIDA

Funding Number: HT942525RCRPIDA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
DOD Duchenne Muscular Dystrophy, Idea Development Award Apply for HT942525DMDRPIDA

Funding Number: HT942525DMDRPIDA
Agency: Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

Inside Our Applicants Portal

  • Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
  • Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
  • Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Access Applicants Portal

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Learn More

 

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "2025 NIST SBIR 02", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.

 

Ask a Question: